Idea for e-mail providers to have as option: you can't login with e-mail aliases to your inbox. So, if you sign up to all websites with your alias account and somehow you expose your alias e-mail address and password you are still safe, because hacker doesn't know primary e-mail for inbox login
@Limax
I use different password for every website and 2fa when available, but I have more than 60 logins and to use different e-mail for each one is a little bit too much. Idea of different e-mail for each site is to minimize damage when someone gets your login credentials and 2fa when recovering passwords. With disabled alias for login this problem is solved, because hacker doesn't know your e-mail for login into your inbox.
@nikolal Actually having a different email for each website is fairly easy with a password manager. But you make some good points.
@nikolal You can also use a different alias (email address) for each website + different password + 2FA.