@kravietz "natural" and "unnatural" are usually proxies for "familiar/understood" and "unfamiliar/not understood". there is also "artificial" vs "natural" which is usually delineated by a thing's origin being human or not.
you are stuck on some semantics that are not important to the question at hand. all of these distinctions are arbitrary. the real issue is one of familiarity. we don't know how gene drives will behave in the wild. we know some very specific and powerful bits of information. we know how to make a gene drive, but we lack the wisdom to predict how it will behave in a large ecosystem.
we are very powerful beings, but we are young and shortsighted. if we aren't careful, we could easily make this planet very difficult to live on. we certainly *should* do and experiment with "unnatural" things, but scope and context need to be taken into account. we have no backup or test planet to work with and no real knowledge of existing in a truly hostile environment for extended periods of time.